BDBM298415 4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-methoxy-phenyl]carbamoylamino]-1-naphthyl]oxy]-2-pyridyl]amino]-N-(2-morpholinoethyl)benzamide::US10125100, Example 17(u)::US10392346, Example 17(u)::US10941115, Example 17(u)

SMILES: COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C

InChI Key: InChIKey=DQGNRAHSEYSADB-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 298415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly by determining the level...				US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...				US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...				US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...				US Patent US10125100 (2018) BindingDB Entry DOI: 10.7270/Q2XW4MV4
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...				US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Oxular Acquisitions Limited US Patent					Assay Description GSK 3α Method 2: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by d...				US Patent US10941115 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...				US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description GSK 3α Method 2: This method follows the same steps as Method 1, but utilises a shorter period of mixing of the test compound (105 minutes inste...				US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV
					More data for this Ligand-Target Pair
p38 MAP kinase alpha/beta (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Oxular Acquisitions Limited US Patent					Assay Description p38 MAPKα Method 2: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen) are evaluated indirectly...				US Patent US10941115 (2021)
					More data for this Ligand-Target Pair
Protein cereblon/Tyrosine-protein kinase SRC (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Oxular Acquisitions Limited US Patent					Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...				US Patent US10941115 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Oxular Acquisitions Limited US Patent					Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...				US Patent US10941115 (2021)
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM298415 (4-[[4-[[4-[[5-tert-butyl-3-(methanesulfonamido)-2-...) Show SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc(cc4)C(=O)NCCN4CCOCC4)c3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C Show InChI InChI=1S/C41H47N7O7S/c1-41(2,3)28-24-34(38(53-4)35(25-28)47-56(5,51)52)46-40(50)45-33-14-15-36(32-9-7-6-8-31(32)33)55-30-16-17-42-37(26-30)44-29-12-10-27(11-13-29)39(49)43-18-19-48-20-22-54-23-21-48/h6-17,24-26,47H,18-23H2,1-5H3,(H,42,44)(H,43,49)(H2,45,46,50)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Topivert Pharma Limited US Patent					Assay Description c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...				US Patent US10392346 (2019) BindingDB Entry DOI: 10.7270/Q2N018WV
					More data for this Ligand-Target Pair