BDBM299582 6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-amine::US9592235, Example 352::US9855269, Compound 248

SMILES: Nc1ncnc2ccc(Oc3cccc(Cl)c3)nc12

InChI Key: InChIKey=ZLSPQBPEHAKXPQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299582   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299582 (6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-a...) Show SMILES Nc1ncnc2ccc(Oc3cccc(Cl)c3)nc12 Show InChI InChI=1S/C13H9ClN4O/c14-8-2-1-3-9(6-8)19-11-5-4-10-12(18-11)13(15)17-7-16-10/h1-7H,(H2,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				J Med Chem 46: 3709-27 (2003) BindingDB Entry DOI: 10.7270/Q2VH5R4B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase kinase 4 (Homo sapiens (Human))	BDBM299582 (6-(3-chloro- phenoxy) pyrido[3,2-d] pyrimidin- 4-a...) Show SMILES Nc1ncnc2ccc(Oc3cccc(Cl)c3)nc12 Show InChI InChI=1S/C13H9ClN4O/c14-8-2-1-3-9(6-8)19-11-5-4-10-12(18-11)13(15)17-7-16-10/h1-7H,(H2,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...				US Patent US9592235 (2017) BindingDB Entry DOI: 10.7270/Q2VX0JKX
					More data for this Ligand-Target Pair