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BDBM299891 4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)pyridin-3- yl]oxy}methyl) piperidin-1-yl]-N- [(2R)- butan-2-yl]-6-[(1- cyanocyclopropyl) methoxy]-1,3,5- triazine-2- carboxamide::US9593097, Example 261

SMILES: CC[C@@H](C)NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1

InChI Key: InChIKey=AQMWHQZTSAKTGW-GOSISDBHSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299891   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))		BDBM299891
PNG
(4-[4-({[2-amino-5- (1-methyl-1H- imidazol-4- yl)py...)
Show SMILES CC[C@@H](C)NC(=O)c1nc(OCC2(CC2)C#N)nc(n1)N1CCC(COc2cc(cnc2N)-c2cn(C)cn2)CC1 |r|
Show InChI InChI=1S/C28H36N10O3/c1-4-18(2)33-25(39)24-34-26(36-27(35-24)41-16-28(15-29)7-8-28)38-9-5-19(6-10-38)14-40-22-11-20(12-31-23(22)30)21-13-37(3)17-32-21/h11-13,17-19H,4-10,14,16H2,1-3H3,(H2,30,31)(H,33,39)/t18-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
 0.0260n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...

US Patent US9593097 (2017)


BindingDB Entry DOI: 10.7270/Q2GM89BD
More data for this
Ligand-Target Pair