BDBM300065 (trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- methoxypropan-2- yl]oxy}-6-[4-(4- methoxy-1H- pyrazolo[3,4- b]pyridin-3- yl)piperidin-1- yl]pyrimidine-4- carboxamide::BDBM300119::US9593097, Example 445::US9593097, Example 446
SMILES: COC[C@@H](C)Oc1nc(cc(n1)C(=O)NC1CCC1O)N1CCC(CC1)c1n[nH]c2nccc(OC)c12
InChI Key:
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM300065 ((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM300065 ((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM300065 ((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.879 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM300065 ((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM300065 ((trans)-N-(2- hydroxy- cyclobutyl)- 2-{[(2R)-1- me...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.02 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. US Patent | Assay Description AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility... | US Patent US9593097 (2017) BindingDB Entry DOI: 10.7270/Q2GM89BD | |||||||||||
More data for this Ligand-Target Pair |