null
SMILES: COc1cc(OC)c(F)c(N2Cc3cnc4NC(=O)C5(CC5)c4c3N(C)C2=O)c1F
InChI Key: InChIKey=PWTLJMXEHHOIKL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation US Patent | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | US Patent US10131667 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XJ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation US Patent | US Patent US10131667 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XJ1 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 3 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation US Patent | US Patent US10131667 (2018) BindingDB Entry DOI: 10.7270/Q2DR2XJ1 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | US Patent US9611267 (2017) BindingDB Entry DOI: 10.7270/Q2N87CVP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.790 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human FGFR1 using biotinylated-EQEDEPEGDYFEWLE peptide as substrate incubated for 1 hr in presence of ATP by FRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00713 BindingDB Entry DOI: 10.7270/Q2S1867R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 3 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | US Patent US9611267 (2017) BindingDB Entry DOI: 10.7270/Q2N87CVP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 1 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NC64C5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NC64C5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 3 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NC64C5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fibroblast growth factor receptor 2 (Homo sapiens (Human)) | BDBM301243 (3'-(2,6-Difluoro-3,5-dimethoxyphenyl)-1'-methyl-4'...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d... | US Patent US9611267 (2017) BindingDB Entry DOI: 10.7270/Q2N87CVP | |||||||||||
More data for this Ligand-Target Pair |