BDBM301999 US9598405, 1.7

SMILES: COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(NC(C)=O)cc(Nc2cc(ccn2)C(F)(F)F)n1

InChI Key: InChIKey=CYPKXPIPMPFLMI-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 301999   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301999 (US9598405, 1.7) Show SMILES COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(NC(C)=O)cc(Nc2cc(ccn2)C(F)(F)F)n1 Show InChI InChI=1S/C26H28F3N5O4S/c1-14(35)32-16-10-18(33-21(11-16)34-20-9-15(6-8-30-20)26(27,28)29)19-12-31-23(39-19)25(37)7-5-17(22(36)38-4)24(2,3)13-25/h6,8-12,17,37H,5,7,13H2,1-4H3,(H2,30,32,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.29	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
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