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SMILES: COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1

InChI Key: InChIKey=HXJMILNCAXTPII-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 302001   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM302001
PNG
(US9598405, 1.9)
Show SMILES COC(=O)C1CCC(O)(CC1(C)C)c1ncc(s1)-c1cc(N)cc(Nc2cc(ccn2)C(F)(F)F)n1
Show InChI InChI=1S/C24H26F3N5O3S/c1-22(2)12-23(34,6-4-15(22)20(33)35-3)21-30-11-17(36-21)16-9-14(28)10-19(31-16)32-18-8-13(5-7-29-18)24(25,26)27/h5,7-11,15,34H,4,6,12H2,1-3H3,(H3,28,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

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antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 5.21n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...

US Patent US9598405 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8V7T
More data for this
Ligand-Target Pair