BDBM30274 carboline analog, 86

SMILES: CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ncc(s1)C(=O)NCCN(C)C

InChI Key: InChIKey=CTXBCAFOAPKNCW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30274   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAPK-Activated Protein Kinase 2 (MK2) (Homo sapiens (Human))	BDBM30274 (carboline analog, 86) Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ncc(s1)C(=O)NCCN(C)C Show InChI InChI=1S/C21H24N6O3S/c1-11-9-23-20(30)17-16(11)13-8-12(4-5-14(13)25-17)18(28)26-21-24-10-15(31-21)19(29)22-6-7-27(2)3/h4-5,8,10-11,25H,6-7,9H2,1-3H3,(H,22,29)(H,23,30)(H,24,26,28)	PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...				Bioorg Med Chem Lett 17: 4664-9 (2007) Article DOI: 10.1016/j.bmcl.2007.05.101 BindingDB Entry DOI: 10.7270/Q23N21QP
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