BDBM30278 indole-based 6-membered lactam, 3c

SMILES: OCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1

InChI Key: InChIKey=RIDYFVBIZGSZQM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30278   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 [41-364] (Homo sapiens (Human))	BDBM30278 (indole-based 6-membered lactam, 3c) Show SMILES OCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1 Show InChI InChI=1S/C18H16N4O3/c23-9-12-7-14-13-6-10(17(24)20-11-2-1-5-19-8-11)3-4-15(13)22-16(14)18(25)21-12/h1-6,8,12,22-23H,7,9H2,(H,20,24)(H,21,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.6	25
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...				Bioorg Med Chem Lett 18: 1994-9 (2008) Article DOI: 10.1016/j.bmcl.2008.01.119 BindingDB Entry DOI: 10.7270/Q2ZW1J8V
					More data for this Ligand-Target Pair