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SMILES: NCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1

InChI Key: InChIKey=FMRWLLNOPBTLDC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30279   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-activated protein kinase 2 [41-364]


(Homo sapiens (Human))		BDBM30279
PNG
(indole-based 6-membered lactam, 3b)
Show SMILES NCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H15N5O2S/c17-7-9-6-11-10-5-8(14(22)21-16-18-3-4-24-16)1-2-12(10)20-13(11)15(23)19-9/h1-5,9,20H,6-7,17H2,(H,19,23)(H,18,21,22)
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Article
PubMed
n/an/a 140n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...

Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair