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SMILES: O=C(Nc1nccs1)c1ccc2cc3C(=O)NCCn3c2c1

InChI Key: InChIKey=RWBKCLCZIDTJJQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30287   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-activated protein kinase 2 [41-364]


(Homo sapiens (Human))		BDBM30287
PNG
(indole-based 6-membered lactam, 22)
Show SMILES O=C(Nc1nccs1)c1ccc2cc3C(=O)NCCn3c2c1
Show InChI InChI=1S/C15H12N4O2S/c20-13(18-15-17-4-6-22-15)10-2-1-9-7-12-14(21)16-3-5-19(12)11(9)8-10/h1-2,4,6-8H,3,5H2,(H,16,21)(H,17,18,20)
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Article
PubMed
n/an/a 1.10E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...

Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair