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SMILES: COc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c2cccn2n(CCC(C)C)c1=O

InChI Key: InChIKey=YJZNZDXWNSYVDU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 30409   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus genotype 1b (isolate BK) (HCV))		BDBM30409
PNG
(pyrrolo[1,2-b]pyridazin-2-one analog., 3b)
Show SMILES COc1ccc2N=C(NS(=O)(=O)c2c1)c1c(O)c2cccn2n(CCC(C)C)c1=O |c:6|
Show InChI InChI=1S/C20H22N4O5S/c1-12(2)8-10-24-20(26)17(18(25)15-5-4-9-23(15)24)19-21-14-7-6-13(29-3)11-16(14)30(27,28)22-19/h4-7,9,11-12,25H,8,10H2,1-3H3,(H,21,22)
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Article
PubMed
n/an/a 2.20E+3n/a 1.70E+4n/an/a7.528



Anadys Pharmaceuticals



Assay Description
Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...

Bioorg Med Chem Lett 18: 3616-21 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.066
BindingDB Entry DOI: 10.7270/Q26D5R9N
More data for this
Ligand-Target Pair