BDBM305171 4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyridin-3-yl)-6-(2- hydroxy-2- methylpropoxy)pyrazolo [1,5-a]pyridine-3- carbonitrile::US10144734, Example 187::US10172845, Example 187::US10441581, Example 187::US10881652, Example 187

SMILES: CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N

InChI Key: InChIKey=YFBPPLOSFGSRRO-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 305171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
RET kinase mutant (V804M) (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
RET Kinase (aa 658-1114) (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
RET kinase mutant (V804M) (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021)
					More data for this Ligand-Target Pair
RET Kinase (V804M) (aa658-end) (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
RET kinase mutant (G810R) (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021)
					More data for this Ligand-Target Pair
RET Kinase (V804M) (aa658-end) (Homo sapiens (Human))	BDBM305171 (4-(6-(3-(3,5- difluorophenoxy)azetidin- 1-yl)pyrid...) Show SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CC(C2)Oc2cc(F)cc(F)c2)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H23F2N5O3/c1-26(2,34)15-35-21-8-23(25-17(9-29)11-31-33(25)14-21)16-3-4-24(30-10-16)32-12-22(13-32)36-20-6-18(27)5-19(28)7-20/h3-8,10-11,14,22,34H,12-13,15H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair