BDBM305738 6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiperidin-1- yl)pyridin-3-yl) pyrazolo[1,5-a]pyridine- 3-carbonitrile::US10144734, Example 756::US10172845, Example 756::US10441581, Example 756::US10881652, Example 756

SMILES: CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N

InChI Key: InChIKey=AAQASFULMJIHHS-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 305738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
RET kinase mutant (V804M) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
RET kinase mutant (G810R) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
RET Kinase (aa 658-1114) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
RET Kinase (V804M) (aa658-end) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
RET kinase mutant (G810R) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description The potency of a compound inhibiting G81 OR mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays containe...				US Patent US10881652 (2021)
					More data for this Ligand-Target Pair
RET Kinase (V804M) (aa658-end) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
RET kinase mutant (G810R) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
RET kinase mutant (V804M) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021)
					More data for this Ligand-Target Pair
RET kinase mutant (V804M) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021)
					More data for this Ligand-Target Pair
RET kinase mutant (G810R) (Homo sapiens (Human))	BDBM305738 (6-ethoxy-4-(6-(4-(3- fluorobenzyl)-4- hydroxypiper...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(O)(Cc3cccc(F)c3)CC2)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H26FN5O2/c1-2-35-23-13-24(26-21(15-29)17-31-33(26)18-23)20-6-7-25(30-16-20)32-10-8-27(34,9-11-32)14-19-4-3-5-22(28)12-19/h3-7,12-13,16-18,34H,2,8-11,14H2,1H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair