BDBM306264 US10144742, Compound I-426

SMILES: COc1cc(ccc1F)-c1nc2cc(ccc2nc1OC(C)C)C(=O)NCc1ccc2nccn2c1

InChI Key: InChIKey=PMBILPMNTOVLBV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306264   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306264 (US10144742, Compound I-426) Show SMILES COc1cc(ccc1F)-c1nc2cc(ccc2nc1OC(C)C)C(=O)NCc1ccc2nccn2c1 Show InChI InChI=1S/C27H24FN5O3/c1-16(2)36-27-25(18-5-7-20(28)23(13-18)35-3)31-22-12-19(6-8-21(22)32-27)26(34)30-14-17-4-9-24-29-10-11-33(24)15-17/h4-13,15-16H,14H2,1-3H3,(H,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
					More data for this Ligand-Target Pair