BDBM306283 US10144742, Compound I-445

SMILES: Cc1ccc(cc1-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1)C(F)(F)F

InChI Key: InChIKey=IOIXQDOCYLQHHL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306283   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM306283 (US10144742, Compound I-445) Show SMILES Cc1ccc(cc1-c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1)C(F)(F)F Show InChI InChI=1S/C29H23F4N5O/c1-17-4-8-20(29(31,32)33)16-22(17)27-26(18-5-9-21(30)10-6-18)37-23-11-7-19(15-24(23)38-27)28(39)36-12-2-3-25-34-13-14-35-25/h4-11,13-16H,2-3,12H2,1H3,(H,34,35)(H,36,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...				US Patent US10144742 (2018) BindingDB Entry DOI: 10.7270/Q2NV9M91
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