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SMILES: CC(C)COc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1

InChI Key: InChIKey=VEOVEHKPBTWSRV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306316   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM306316
PNG
(US10144742, Compound I-478)
Show SMILES CC(C)COc1nc2ccc(cc2nc1-c1ccc(F)cc1)C(=O)NCCCc1ncc[nH]1
Show InChI InChI=1S/C25H26FN5O2/c1-16(2)15-33-25-23(17-5-8-19(26)9-6-17)30-21-14-18(7-10-20(21)31-25)24(32)29-11-3-4-22-27-12-13-28-22/h5-10,12-14,16H,3-4,11,15H2,1-2H3,(H,27,28)(H,29,32)
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US Patent
n/an/a<100n/an/an/an/an/an/a



Millennium Pharmaceuticals, Inc.

US Patent


Assay Description
To measure the inhibition of NAMPT activity hNAMPT protein stock and anti 6His-Tb (Cisbio; Cat. No. 61HISTLB) is diluted to 3× final concentration wi...

US Patent US10144742 (2018)


BindingDB Entry DOI: 10.7270/Q2NV9M91
More data for this
Ligand-Target Pair