BDBM306735 3-fluoro-N-(2- (3-fluoro-4- ((1R,3R)-2-((1- fluorocyclo- propyl)methyl)- 3-methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)phenoxy) ethyl)propan- 1-amine::US10149839, Example 21

SMILES: C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1ccc(OCCNCCCF)cc1F

InChI Key:

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 306735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM306735 (3-fluoro-N-(2- (3-fluoro-4- ((1R,3R)-2-((1- fluoro...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1ccc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM306735 (3-fluoro-N-(2- (3-fluoro-4- ((1R,3R)-2-((1- fluoro...) Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC1(F)CC1)c1ccc(OCCNCCCF)cc1F |r| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca AB US Patent					Assay Description Compounds were dosed directly from a compound source microplate containing serially diluted compound (4 wells containing 10 mM, 0.1 mM, 1 mM and 10 n...				US Patent US10149839 (2018) BindingDB Entry DOI: 10.7270/Q28P62M5
					More data for this Ligand-Target Pair