null

SMILES: CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@@H]2C(O)=O)cc1OC

InChI Key: InChIKey=RAOIMTPEPSLKEC-NZQKXSOJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 307527   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM307527 ((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@@H]2C(O)=O)cc1OC |r| Show InChI InChI=1S/C27H41N5O5/c1-4-7-20(11-14-33)30-25-22(18(2)29-27(28)31-25)16-19-9-10-21(17-24(19)36-3)37-15-6-13-32-12-5-8-23(32)26(34)35/h9-10,17,20,23,33H,4-8,11-16H2,1-3H3,(H,34,35)(H3,28,29,30,31)/t20-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.90E+3	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...				US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM307527 ((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@@H]2C(O)=O)cc1OC |r| Show InChI InChI=1S/C27H41N5O5/c1-4-7-20(11-14-33)30-25-22(18(2)29-27(28)31-25)16-19-9-10-21(17-24(19)36-3)37-15-6-13-32-12-5-8-23(32)26(34)35/h9-10,17,20,23,33H,4-8,11-16H2,1-3H3,(H,34,35)(H3,28,29,30,31)/t20-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr...				US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM307527 ((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@@H]2C(O)=O)cc1OC |r| Show InChI InChI=1S/C27H41N5O5/c1-4-7-20(11-14-33)30-25-22(18(2)29-27(28)31-25)16-19-9-10-21(17-24(19)36-3)37-15-6-13-32-12-5-8-23(32)26(34)35/h9-10,17,20,23,33H,4-8,11-16H2,1-3H3,(H,34,35)(H3,28,29,30,31)/t20-,23+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM307527 ((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@@H]2C(O)=O)cc1OC |r| Show InChI InChI=1S/C27H41N5O5/c1-4-7-20(11-14-33)30-25-22(18(2)29-27(28)31-25)16-19-9-10-21(17-24(19)36-3)37-15-6-13-32-12-5-8-23(32)26(34)35/h9-10,17,20,23,33H,4-8,11-16H2,1-3H3,(H,34,35)(H3,28,29,30,31)/t20-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description TLR8/NF-kB/SEAPorter™ HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the sec...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM307527 ((R)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@@H]2C(O)=O)cc1OC |r| Show InChI InChI=1S/C27H41N5O5/c1-4-7-20(11-14-33)30-25-22(18(2)29-27(28)31-25)16-19-9-10-21(17-24(19)36-3)37-15-6-13-32-12-5-8-23(32)26(34)35/h9-10,17,20,23,33H,4-8,11-16H2,1-3H3,(H,34,35)(H3,28,29,30,31)/t20-,23+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	126	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair