BDBM307528 (S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenoxy)propyl)pyrrolidine-2-carboxylic acid::US10150743, Example 9::US10562861, Ex. No. 9
SMILES: CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN2CCC[C@H]2C(O)=O)cc1OC
InChI Key: InChIKey=RAOIMTPEPSLKEC-REWPJTCUSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM307528 ((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a |
Sumitomo Dainippon Pharma Co., Ltd. US Patent | Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep... | US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM307528 ((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a |
Sumitomo Dainippon Pharma Co., Ltd. US Patent | Assay Description TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr... | US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanin-concentrating hormone receptor 2/HERG (Homo sapiens (Human)) | BDBM307528 ((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sumitomo Dainippon Pharma Co., Ltd. US Patent | Assay Description The hERG potassium current was measured in a hERG-stably-expressing Chinese hamster ovary K1 (CHO) cells. The experiments were performed using an aut... | US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM307528 ((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Sumitomo Dainippon Pharma Co., Ltd. US Patent | Assay Description TLR8/NF-kB/SEAPorter™ HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the sec... | US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM307528 ((S)-1-(3-(4-((2-amino-4-((S)-1-hydroxyhexan-3-ylam...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
Sumitomo Dainippon Pharma Co., Ltd. US Patent | Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep... | US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT | |||||||||||
More data for this Ligand-Target Pair |