BDBM307531 (S)-2-((3-(4-((2-amino-4-(l-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenoxy)propyl)(2,2-difluoroethyl)amino)acetic acid::US10150743, Example 12::US10562861, Ex. No. 12

SMILES: CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN(CC(F)F)CC(O)=O)cc1OC

InChI Key: InChIKey=OZVFUUXGCDMGIG-IBGZPJMESA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 307531   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM307531 ((S)-2-((3-(4-((2-amino-4-(l-hydroxyhexan-3-ylamino...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN(CC(F)F)CC(O)=O)cc1OC |r| Show InChI InChI=1S/C26H39F2N5O5/c1-4-6-19(9-11-34)31-25-21(17(2)30-26(29)32-25)13-18-7-8-20(14-22(18)37-3)38-12-5-10-33(15-23(27)28)16-24(35)36/h7-8,14,19,23,34H,4-6,9-13,15-16H2,1-3H3,(H,35,36)(H3,29,30,31,32)/t19-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...				US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM307531 ((S)-2-((3-(4-((2-amino-4-(l-hydroxyhexan-3-ylamino...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN(CC(F)F)CC(O)=O)cc1OC |r| Show InChI InChI=1S/C26H39F2N5O5/c1-4-6-19(9-11-34)31-25-21(17(2)30-26(29)32-25)13-18-7-8-20(14-22(18)37-3)38-12-5-10-33(15-23(27)28)16-24(35)36/h7-8,14,19,23,34H,4-6,9-13,15-16H2,1-3H3,(H,35,36)(H3,29,30,31,32)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description TLR8/NF-kB/SEAPorter™ HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the sec...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM307531 ((S)-2-((3-(4-((2-amino-4-(l-hydroxyhexan-3-ylamino...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN(CC(F)F)CC(O)=O)cc1OC |r| Show InChI InChI=1S/C26H39F2N5O5/c1-4-6-19(9-11-34)31-25-21(17(2)30-26(29)32-25)13-18-7-8-20(14-22(18)37-3)38-12-5-10-33(15-23(27)28)16-24(35)36/h7-8,14,19,23,34H,4-6,9-13,15-16H2,1-3H3,(H,35,36)(H3,29,30,31,32)/t19-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM307531 ((S)-2-((3-(4-((2-amino-4-(l-hydroxyhexan-3-ylamino...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(OCCCN(CC(F)F)CC(O)=O)cc1OC |r| Show InChI InChI=1S/C26H39F2N5O5/c1-4-6-19(9-11-34)31-25-21(17(2)30-26(29)32-25)13-18-7-8-20(14-22(18)37-3)38-12-5-10-33(15-23(27)28)16-24(35)36/h7-8,14,19,23,34H,4-6,9-13,15-16H2,1-3H3,(H,35,36)(H3,29,30,31,32)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr...				US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N
					More data for this Ligand-Target Pair