BDBM307533 (S)-1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)-1H-imidazole-5-carboxylic acid::US10150743, Example 14::US10562861, Ex. No. 14

SMILES: CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(Cn2cncc2C(O)=O)cc1OC

InChI Key: InChIKey=CTZXFKZRJMILBC-SFHVURJKSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 307533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM307533 ((S)-1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(Cn2cncc2C(O)=O)cc1OC |r| Show InChI InChI=1S/C24H32N6O4/c1-4-5-18(8-9-31)28-22-19(15(2)27-24(25)29-22)11-17-7-6-16(10-21(17)34-3)13-30-14-26-12-20(30)23(32)33/h6-7,10,12,14,18,31H,4-5,8-9,11,13H2,1-3H3,(H,32,33)(H3,25,27,28,29)/t18-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...				US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM307533 ((S)-1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(Cn2cncc2C(O)=O)cc1OC |r| Show InChI InChI=1S/C24H32N6O4/c1-4-5-18(8-9-31)28-22-19(15(2)27-24(25)29-22)11-17-7-6-16(10-21(17)34-3)13-30-14-26-12-20(30)23(32)33/h6-7,10,12,14,18,31H,4-5,8-9,11,13H2,1-3H3,(H,32,33)(H3,25,27,28,29)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description TLR8/NF-kB/SEAPorter™ HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the sec...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM307533 ((S)-1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(Cn2cncc2C(O)=O)cc1OC |r| Show InChI InChI=1S/C24H32N6O4/c1-4-5-18(8-9-31)28-22-19(15(2)27-24(25)29-22)11-17-7-6-16(10-21(17)34-3)13-30-14-26-12-20(30)23(32)33/h6-7,10,12,14,18,31H,4-5,8-9,11,13H2,1-3H3,(H,32,33)(H3,25,27,28,29)/t18-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description Recombinant human TLR7 was stably expressed in a HEK293 cell line already stably expressing the pNiFty2-SEAP reporter plasmid; integration of the rep...				US Patent US10562861 (2020) BindingDB Entry DOI: 10.7270/Q22F7QTT
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM307533 ((S)-1-(4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-...) Show SMILES CCC[C@@H](CCO)Nc1nc(N)nc(C)c1Cc1ccc(Cn2cncc2C(O)=O)cc1OC |r| Show InChI InChI=1S/C24H32N6O4/c1-4-5-18(8-9-31)28-22-19(15(2)27-24(25)29-22)11-17-7-6-16(10-21(17)34-3)13-30-14-26-12-20(30)23(32)33/h6-7,10,12,14,18,31H,4-5,8-9,11,13H2,1-3H3,(H,32,33)(H3,25,27,28,29)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Sumitomo Dainippon Pharma Co., Ltd. US Patent					Assay Description TLR8/NF-kB/SEAPorter HEK 293 Cell Line (Imgenex Corporation) is a stably co-transfected cell line which expresses full-length human TLR8 and the secr...				US Patent US10150743 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K6N
					More data for this Ligand-Target Pair