BDBM307536 5-(4-Fluoro-3-((1-(pyrimidin-2-yl)cyclopropyl)carbamoyl)phenyl)-2-(4-fluorophenyl)-N-methyl-6-(2,2,2-trifluoroethoxy)benzofuran-3-carboxamide::US10150747, Example 3

SMILES: CNC(=O)c1c(oc2cc(OCC(F)(F)F)c(cc12)-c1ccc(F)c(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1

InChI Key: InChIKey=JRZBBRXUSGQMPD-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307536   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RNA polymerase (NS5B) (Hepatitis C virus (HCV))	BDBM307536 (5-(4-Fluoro-3-((1-(pyrimidin-2-yl)cyclopropyl)carb...) Show SMILES CNC(=O)c1c(oc2cc(OCC(F)(F)F)c(cc12)-c1ccc(F)c(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H23F5N4O4/c1-38-29(43)26-22-14-20(24(44-16-32(35,36)37)15-25(22)45-27(26)17-3-6-19(33)7-4-17)18-5-8-23(34)21(13-18)28(42)41-31(9-10-31)30-39-11-2-12-40-30/h2-8,11-15H,9-10,16H2,1H3,(H,38,43)(H,41,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.70	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...				US Patent US10150747 (2018) BindingDB Entry DOI: 10.7270/Q2H70HWJ
					More data for this Ligand-Target Pair
RNA polymerase (NS5B) (Hepatitis C virus (HCV))	BDBM307536 (5-(4-Fluoro-3-((1-(pyrimidin-2-yl)cyclopropyl)carb...) Show SMILES CNC(=O)c1c(oc2cc(OCC(F)(F)F)c(cc12)-c1ccc(F)c(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1 Show InChI InChI=1S/C32H23F5N4O4/c1-38-29(43)26-22-14-20(24(44-16-32(35,36)37)15-25(22)45-27(26)17-3-6-19(33)7-4-17)18-5-8-23(34)21(13-18)28(42)41-31(9-10-31)30-39-11-2-12-40-30/h2-8,11-15H,9-10,16H2,1H3,(H,38,43)(H,41,42)	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.38	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...				US Patent US10150747 (2018) BindingDB Entry DOI: 10.7270/Q2H70HWJ
					More data for this Ligand-Target Pair