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BDBM307559 5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamoyl)-4-methoxyphenyl)-2-(4-fluorophenyl)-6-isobutoxy-N-methylbenzofuran-3-carboxamide::US10150747, Example 26

SMILES: CNC(=O)c1c(oc2cc(OCC(C)C)c(cc12)-c1ccc(OC)c(c1)C(=O)NC(C)(C)c1ncon1)-c1ccc(F)cc1

InChI Key: InChIKey=XTBZEMGTXLZZOP-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307559   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM307559
PNG
(5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamo...)
Show SMILES CNC(=O)c1c(oc2cc(OCC(C)C)c(cc12)-c1ccc(OC)c(c1)C(=O)NC(C)(C)c1ncon1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H33FN4O6/c1-18(2)16-42-26-15-27-23(28(31(40)35-5)29(44-27)19-7-10-21(34)11-8-19)14-22(26)20-9-12-25(41-6)24(13-20)30(39)37-33(3,4)32-36-17-43-38-32/h7-15,17-18H,16H2,1-6H3,(H,35,40)(H,37,39)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 80n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10150747 (2018)


BindingDB Entry DOI: 10.7270/Q2H70HWJ
More data for this
Ligand-Target Pair
RNA polymerase (NS5B)


(Hepatitis C virus (HCV))
BDBM307559
PNG
(5-(3-((2-(1,2,4-oxadiazol-3-yl)propan-2-yl)carbamo...)
Show SMILES CNC(=O)c1c(oc2cc(OCC(C)C)c(cc12)-c1ccc(OC)c(c1)C(=O)NC(C)(C)c1ncon1)-c1ccc(F)cc1
Show InChI InChI=1S/C33H33FN4O6/c1-18(2)16-42-26-15-27-23(28(31(40)35-5)29(44-27)19-7-10-21(34)11-8-19)14-22(26)20-9-12-25(41-6)24(13-20)30(39)37-33(3,4)32-36-17-43-38-32/h7-15,17-18H,16H2,1-6H3,(H,35,40)(H,37,39)
PDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
To evaluate compound efficacy, titrated compounds were transferred to sterile 384-well tissue culture treated plates, and the plates were seeded with...


US Patent US10150747 (2018)


BindingDB Entry DOI: 10.7270/Q2H70HWJ
More data for this
Ligand-Target Pair