BDBM307648 2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridin-2-yl)-6- (pyridin-3- yl)isoindolin-1-one::US10150755, Compound 40
SMILES: O=C1N(Cc2ccc(cc12)-c1cccnc1)c1cccc(n1)-c1nncn1C1CC1
InChI Key: InChIKey=BSUVXSRGIZBFQS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM307648 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myosin light chain kinase, smooth muscle (Homo sapiens (Human)) | BDBM307648 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myosin light chain kinase, smooth muscle (Homo sapiens (Human)) | BDBM307648 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM307648 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tumor necrosis factor (Homo sapiens (Human)) | BDBM307648 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q27P91GS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tumor necrosis factor (Homo sapiens (Human)) | BDBM307648 (2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <200 | n/a | n/a | n/a | n/a | n/a | n/a |
SEAL ROCK THERAPEUTICS, INC. US Patent | Assay Description Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea... | US Patent US10150755 (2018) BindingDB Entry DOI: 10.7270/Q2125VQ8 | |||||||||||
More data for this Ligand-Target Pair |