BDBM307759 N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-N,N-dimethylbutane-1,4-diamine::US9650358, Example 55

SMILES: CN(C)CCCCNc1cc(c(Cl)cn1)-c1ccc2ncn(Cc3cccc(F)c3)c2c1

InChI Key: InChIKey=NSVAYXHCYNUAEH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307759   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307759 ( N′-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzi...) Show SMILES CN(C)CCCCNc1cc(c(Cl)cn1)-c1ccc2ncn(Cc3cccc(F)c3)c2c1 Show InChI InChI=1S/C25H27ClFN5/c1-31(2)11-4-3-10-28-25-14-21(22(26)15-29-25)19-8-9-23-24(13-19)32(17-30-23)16-18-6-5-7-20(27)12-18/h5-9,12-15,17H,3-4,10-11,16H2,1-2H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
					More data for this Ligand-Target Pair