BDBM307893 N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-oxocyclobutanecarboxamide::US9650358, Example 189

SMILES: Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)C3CC(=O)C3)ncc2Cl)c1

InChI Key: InChIKey=HEVFRDDWFUPZRH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307893   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM307893 (N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-...) Show SMILES Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC(=O)C3CC(=O)C3)ncc2Cl)c1 Show InChI InChI=1S/C24H18ClFN4O2/c25-20-11-27-23(29-24(32)16-7-18(31)8-16)10-19(20)15-4-5-21-22(9-15)30(13-28-21)12-14-2-1-3-17(26)6-14/h1-6,9-11,13,16H,7-8,12H2,(H,27,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...				US Patent US9650358 (2017) BindingDB Entry DOI: 10.7270/Q2057J0M
					More data for this Ligand-Target Pair