null

SMILES: Cn1cc(cn1)C1=NCC(=O)N2CCc3c(I)cccc3C2=C1

InChI Key: InChIKey=GGNUBGHBZKNFOS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 308098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM308098 (US9650377, Example 32) Show SMILES Cn1cc(cn1)C1=NCC(=O)N2CCc3c(I)cccc3C2=C1 |c:24,t:7| Show InChI InChI=1S/C17H15IN4O/c1-21-10-11(8-20-21)15-7-16-13-3-2-4-14(18)12(13)5-6-22(16)17(23)9-19-15/h2-4,7-8,10H,5-6,9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...				US Patent US9650377 (2017) BindingDB Entry DOI: 10.7270/Q2G73GT2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM308098 (US9650377, Example 32) Show SMILES Cn1cc(cn1)C1=NCC(=O)N2CCc3c(I)cccc3C2=C1 |c:24,t:7| Show InChI InChI=1S/C17H15IN4O/c1-21-10-11(8-20-21)15-7-16-13-3-2-4-14(18)12(13)5-6-22(16)17(23)9-19-15/h2-4,7-8,10H,5-6,9H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...				US Patent US9650377 (2017) BindingDB Entry DOI: 10.7270/Q2G73GT2
					More data for this Ligand-Target Pair