BindingDB PrimarySearch

BDBM309529 3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione::US10945994, Compound 1::US9603836, Compound 1::US9603836, Compound 1a::US9949951, 1a

SMILES: Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1

InChI Key:

Data: 36 IC50 3 Kd

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 309529
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
ITEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US9603836 (2017) BindingDB Entry DOI: 10.7270/Q2MK6FZ8
ITEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US10945994 (2021)
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
University of Tampere					Assay Description The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...				J Med Chem 52: 646-54 (2009) BindingDB Entry DOI: 10.7270/Q2959KW7
University of Tampere					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
University of Tampere					Assay Description The compounds of the present invention inhibit the enzymatic activity of human IDO1.To measure enzymatic activity of human IDO1, the reaction mixture...				J Med Chem 52: 646-54 (2009) BindingDB Entry DOI: 10.7270/Q2959KW7
University of Tampere					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Binding affinity to ferrous form of human recombinant IDO-1				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of CYP3A4 (unknown origin)				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	7.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of CYP2C19 (unknown origin)				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of CYP2C9 (unknown origin)				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of CYP1A2 (unknown origin)				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human THP1 cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB method				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of IDO-1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine production after 16 to 24 hrs by PDMAB method				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Mus musculus)	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of mouse IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS method				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of human recombinant IDO-1 using tryptophan as substrate after 22 mins by LC-MS/MS method				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of human recombinant IDO-1 using L-Trp as substrate after 15 mins by PDMAB-based assay				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of human TDO2 using tryptophan as substrate after 22 mins by LC-MS/MS method				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	2.23E+4	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Binding affinity to ferric form of human recombinant IDO-1				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of IDO-1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine production after 24 hrs by LC-MS/MS method				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Binding affinity to ferric form of human recombinant IDO-1 in absence of oxygen				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Broad substrate specificity ATP-binding cassette transporter ABCG2 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	6.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
iTeos Therapeutics Curated by ChEMBL					Assay Description Inhibition of BCRP (unknown origin) transfected in MDCK cells assessed as decrease in pitavastatin transport				J Med Chem 60: 9617-9629 (2017) Article DOI: 10.1021/acs.jmedchem.7b00974 BindingDB Entry DOI: 10.7270/Q2ZP48M3
iTeos Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCs				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Transcriptional activation in CV-1 cells expressing human glucocorticoid receptor				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCs				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human recombinant IDO1 assessed as reduction in kynurenine production incubated fro 15 mins using L-Trp substrate				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of TDO (unknown origin)				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Mus musculus)	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of IDO1 in mouse P815 Clone 12 cells assessed as reduction in kynurenine production incubated for 16 to 18 hrs				Eur J Med Chem 143: 656-669 (2018) Article DOI: 10.1016/j.ejmech.2017.11.088 BindingDB Entry DOI: 10.7270/Q2GX4F22
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant full-length human IDO1 by mass spectrometric analysis				J Med Chem 63: 1642-1659 (2020) Article DOI: 10.1021/acs.jmedchem.9b01549
National Health Research Institutes Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of TDO (unknown origin)				ACS Med Chem Lett 11: 541-549 (2020) Article DOI: 10.1021/acsmedchemlett.0c00004
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.78E+5	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College Curated by ChEMBL					Assay Description Inhibition of human TDO expressed in human T-REx cells using L-tryptophan as substrate after 20 hrs				Eur J Med Chem 162: 455-464 (2019) Article DOI: 10.1016/j.ejmech.2018.11.010
Bryn Mawr College Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College Curated by ChEMBL					Assay Description Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate after 20 hrs				Eur J Med Chem 162: 455-464 (2019) Article DOI: 10.1016/j.ejmech.2018.11.010
Bryn Mawr College Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 2 (Mus musculus)	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	3.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
Bryn Mawr College Curated by ChEMBL					Assay Description Inhibition of mouse IDO2 expressed in human T-REx cells using L-tryptophan as substrate after 20 hrs				Eur J Med Chem 162: 455-464 (2019) Article DOI: 10.1016/j.ejmech.2018.11.010
Bryn Mawr College Curated by ChEMBL					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Tongji University Curated by ChEMBL					Assay Description Inhibition of recombinant human full length IDO1 by mass spectrometry based enzymatic assay				Bioorg Med Chem Lett 30: (2020)
Tongji University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US10945994 (2021)
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)
Indoleamine 2,3-dioxygenase 1 (Mus musculus)	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US10945994 (2021)
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Dog)	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US10945994 (2021)
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US10945994 (2021)
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair
Tryptophan 2,3-dioxygenase (Mus musculus)	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US10945994 (2021)
Pfizer Inc.; iTEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair
Indoleamine 2,3-dioxygenase 1 (Homo sapiens (Human))	BDBM309529 (3-(5-fluoro-1H-indol-3- yl)pyrrolidine-2,5-dione \|...) Show SMILES Fc1ccc2[nH]cc(C3CC(=O)NC3=O)c2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
ITEOS THERAPEUTICS US Patent					Assay Description To measure enzymatic activity of human IDO1, the reaction mixture contained (final concentrations) potassium phosphate buffer (50 mM, pH 6.5), ascorb...				US Patent US9603836 (2017) BindingDB Entry DOI: 10.7270/Q2MK6FZ8
ITEOS THERAPEUTICS US Patent					More data for this Ligand-Target Pair				3D Structure (crystal)