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SMILES: Cn1cc(-c2ccc3NC(=O)CC(Nc3c2)c2cccs2)c2cc[nH]c2c1=O

InChI Key:

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310880   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4 [42-168]


(Homo sapiens (Human))		BDBM310880
PNG
(7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4...)
Show SMILES Cn1cc(-c2ccc3NC(=O)CC(Nc3c2)c2cccs2)c2cc[nH]c2c1=O
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 58n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...

US Patent US10150767 (2018)


BindingDB Entry DOI: 10.7270/Q2V98B5W
More data for this
Ligand-Target Pair