BDBM310909 4-[4-(3,3-difluoroazetidine-1-carbonyl)phenyl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10150767, Example 28

SMILES: Cn1cc(-c2ccc(cc2)C(=O)N2CC(F)(F)C2)c2cc[nH]c2c1=O

InChI Key: InChIKey=PUFVEJIMVVWRJA-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310909   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Chromatin remodeling regulator CECR2 [424-538] (Homo sapiens (Human))	BDBM310909 (4-[4-(3,3-difluoroazetidine-1-carbonyl)phenyl]-6-m...) Show SMILES Cn1cc(-c2ccc(cc2)C(=O)N2CC(F)(F)C2)c2cc[nH]c2c1=O Show InChI InChI=1S/C18H15F2N3O2/c1-22-8-14(13-6-7-21-15(13)17(22)25)11-2-4-12(5-3-11)16(24)23-9-18(19,20)10-23/h2-8,21H,9-10H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc.; Constellation Pharmaceuticals Inc. US Patent					Assay Description His/Flag epitope tagged CECR2424-538 was cloned, expressed, and purified to homogeneity. CECR2 binding and inhibition was assessed by monitoring the ...				US Patent US10150767 (2018) BindingDB Entry DOI: 10.7270/Q2V98B5W
					More data for this Ligand-Target Pair