null

SMILES: CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F

InChI Key: InChIKey=HPNKCULQQWRCGT-QHCPKHFHSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 311304   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311304 (((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...) Show SMILES CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F |r| Show InChI InChI=1S/C23H30ClF2N3O3/c1-14(2)12-23(6,29-21(30)32-22(3,4)5)13-31-18-8-7-16(28-19(18)24)15-9-10-27-17(11-15)20(25)26/h7-11,14,20H,12-13H2,1-6H3,(H,29,30)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10155760 (2018) BindingDB Entry DOI: 10.7270/Q2F191S4
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311304 (((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...) Show SMILES CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F |r| Show InChI InChI=1S/C23H30ClF2N3O3/c1-14(2)12-23(6,29-21(30)32-22(3,4)5)13-31-18-8-7-16(28-19(18)24)15-9-10-27-17(11-15)20(25)26/h7-11,14,20H,12-13H2,1-6H3,(H,29,30)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2930WGG
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311304 (((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...) Show SMILES CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F |r| Show InChI InChI=1S/C23H30ClF2N3O3/c1-14(2)12-23(6,29-21(30)32-22(3,4)5)13-31-18-8-7-16(28-19(18)24)15-9-10-27-17(11-15)20(25)26/h7-11,14,20H,12-13H2,1-6H3,(H,29,30)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c02131 BindingDB Entry DOI: 10.7270/Q2X63RT2
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311304 (((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...) Show SMILES CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F |r| Show InChI InChI=1S/C23H30ClF2N3O3/c1-14(2)12-23(6,29-21(30)32-22(3,4)5)13-31-18-8-7-16(28-19(18)24)15-9-10-27-17(11-15)20(25)26/h7-11,14,20H,12-13H2,1-6H3,(H,29,30)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10544120 (2020) BindingDB Entry DOI: 10.7270/Q2RF5XCX
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311304 (((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...) Show SMILES CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F |r| Show InChI InChI=1S/C23H30ClF2N3O3/c1-14(2)12-23(6,29-21(30)32-22(3,4)5)13-31-18-8-7-16(28-19(18)24)15-9-10-27-17(11-15)20(25)26/h7-11,14,20H,12-13H2,1-6H3,(H,29,30)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...				US Patent US10723734 (2020) BindingDB Entry DOI: 10.7270/Q2Z60S4P
					More data for this Ligand-Target Pair
AP2-associated protein kinase 1 (Homo sapiens (Human))	BDBM311304 (((S)-1-((6-chloro-2′-(difluoromethyl)-[2,4&#...) Show SMILES CC(C)C[C@](C)(N)COc1ccc(nc1Cl)-c1ccnc(c1)C(F)F |r| Show InChI InChI=1S/C23H30ClF2N3O3/c1-14(2)12-23(6,29-21(30)32-22(3,4)5)13-31-18-8-7-16(28-19(18)24)15-9-10-27-17(11-15)20(25)26/h7-11,14,20H,12-13H2,1-6H3,(H,29,30)/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Co. US Patent					Assay Description The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...				US Patent US10351563 (2019) BindingDB Entry DOI: 10.7270/Q2P55QWS
					More data for this Ligand-Target Pair