BDBM311731 Ex. Cpd. 183::US10807986, Example 183
SMILES: COCc1ccc(NC(=O)c2c(C#CC3CCN(C)CC3)n(c3ncnc(N)c23)C2(C)CC2)cc1
InChI Key: InChIKey=SWEVAXPAHGPDHE-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that... | US Patent US10155768 (2018) BindingDB Entry DOI: 10.7270/Q2X350J3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L) (i.e., RET with V804L mutation) kinase acti... | US Patent US10155768 (2018) BindingDB Entry DOI: 10.7270/Q2X350J3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RET kinase mutant (V804M) (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description RET (V804M) (i.e., RET with V804M mutation) kinase activity was measured using purified recombinant human RET (V804M) protein purchased from Eurofins... | US Patent US10155768 (2018) BindingDB Entry DOI: 10.7270/Q2X350J3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that... | US Patent US10807986 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RET kinase mutant (V804M) (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L or V804M) (i.e., RET with V804L or V804M mut... | US Patent US10807986 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RET kinase mutant (V804M) (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RET kinase mutant (V804L) (Homo sapiens (Human)) | BDBM311731 (Ex. Cpd. 183 | US10807986, Example 183 | US1104669...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Taiho Pharmaceutical Co., Ltd. US Patent | Assay Description Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L or V804M) (i.e., RET with V804L or V804M mut... | US Patent US10807986 (2020) | |||||||||||
More data for this Ligand-Target Pair |