BDBM31177 thiazol-2-amine, 7
SMILES: COc1ccc(cc1OC)-c1csc(N)n1
InChI Key: InChIKey=QNLNRENPKAQTMJ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Runt-Related Transcription Factor 1 Isoform AML1C (Homo sapiens (Human)) | BDBM31177 (thiazol-2-amine, 7) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia at Charlottesville | Assay Description His6-CBFbeta (1-141) was expressed and purified with the exception of the protease cleavage step. Cerulean-Runt domain fusion protein (Runx1 41-190) ... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Runt-Related Transcription Factor 1 Isoform AML1C (Homo sapiens (Human)) | BDBM31177 (thiazol-2-amine, 7) | PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.05E+4 | n/a | n/a | n/a | n/a | 7.5 | 23 |
University of Virginia at Charlottesville | Assay Description For the FRET measurements, the Cerulean-Runt (Runx1 41-190) and Venus-CBFbeta (1-141) fusion proteins were dialyzed into FRET assay buffer. Protein c... | Chem Biol 14: 1186-97 (2007) Article DOI: 10.1016/j.chembiol.2007.09.006 BindingDB Entry DOI: 10.7270/Q2862DTN | |||||||||||
More data for this Ligand-Target Pair |