BDBM311846 5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl)-7-methylindolin-2-one::US10155769, Example 87
SMILES: Cc1cc(cc2CC(=O)Nc12)-c1c(ccn2cc(nc12)C(F)(F)F)C(F)(F)F
InChI Key: InChIKey=HDWDXSUOBZTWFG-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human)) | BDBM311846 (5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.398 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8... | US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC | |||||||||||
More data for this Ligand-Target Pair |