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SMILES: CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c(N)s2)C1=O

InChI Key: InChIKey=PNYBHJVQEDZSEB-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312905   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM312905 (5-amino-2-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...) Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c(N)s2)C1=O |r| Show InChI InChI=1S/C17H16N4O3S/c1-21-8-7-17(24,16(21)23)6-5-10-3-2-4-11(9-10)15-20-12(13(18)22)14(19)25-15/h2-4,9,24H,7-8,19H2,1H3,(H2,18,22)/t17-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...				US Patent US9605005 (2017) BindingDB Entry DOI: 10.7270/Q2T43W61
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 14 (Homo sapiens (Human))	BDBM312905 (5-amino-2-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...) Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c(N)s2)C1=O |r| Show InChI InChI=1S/C17H16N4O3S/c1-21-8-7-17(24,16(21)23)6-5-10-3-2-4-11(9-10)15-20-12(13(18)22)14(19)25-15/h2-4,9,24H,7-8,19H2,1H3,(H2,18,22)/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description The ability of the nuclear factor-kappa B (NF-kB)-inducing kinase (NIK) to catalyze the hydrolysis of adenosine-5′-triphosphate (ATP) was monit...				US Patent US10550117 (2020) BindingDB Entry DOI: 10.7270/Q2959KZ4
					More data for this Ligand-Target Pair