BDBM312948 3-[1-(4-Chloro-2-fluorobenzyl)-5-fluoro-6-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one::US9605008, 9

SMILES: Cc1nc2n(Cc3ccc(Cl)cc3F)nc(-c3nnc4c(NC(=O)C4(C)C)n3)c2cc1F

InChI Key: InChIKey=BJNJMOWXFKTBEK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM312948 (3-[1-(4-Chloro-2-fluorobenzyl)-5-fluoro-6-methyl-1...) Show SMILES Cc1nc2n(Cc3ccc(Cl)cc3F)nc(-c3nnc4c(NC(=O)C4(C)C)n3)c2cc1F Show InChI InChI=1S/C21H16ClF2N7O/c1-9-13(23)7-12-15(17-26-18-16(28-29-17)21(2,3)20(32)27-18)30-31(19(12)25-9)8-10-4-5-11(22)6-14(10)24/h4-7H,8H2,1-3H3,(H,26,27,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...				US Patent US9605008 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BC2
					More data for this Ligand-Target Pair