BDBM313078 N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine::US10166216, Compound 57

SMILES: Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1ccccn1

InChI Key: InChIKey=KBRBXIZYOCIACM-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313078   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM313078 (N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...) Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1ccccn1 Show InChI InChI=1S/C19H22FN7O/c20-15-13-14(6-7-16(15)28-12-11-26-9-3-4-10-26)23-19-24-18(21)27(25-19)17-5-1-2-8-22-17/h1-2,5-8,13H,3-4,9-12H2,(H3,21,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	334	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net. Curated by ChEMBL					Assay Description Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...				Bioorg Med Chem Lett 27: 3766-3771 (2017) Article DOI: 10.1016/j.bmcl.2017.06.071 BindingDB Entry DOI: 10.7270/Q26D5WH0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM313078 (N3-(3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...) Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1ccccn1 Show InChI InChI=1S/C19H22FN7O/c20-15-13-14(6-7-16(15)28-12-11-26-9-3-4-10-26)23-19-24-18(21)27(25-19)17-5-1-2-8-22-17/h1-2,5-8,13H,3-4,9-12H2,(H3,21,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...				US Patent US10166216 (2019) BindingDB Entry DOI: 10.7270/Q21N836F
					More data for this Ligand-Target Pair