BDBM3139 2-pyridinone deriv. 45::5-ethyl-3-{[(3-methoxypyridin-2-yl)methyl]amino}-6-methyl-1,2-dihydropyridin-2-one

SMILES: CCc1cc(NCc2ncccc2OC)c(=O)[nH]c1C

InChI Key: InChIKey=KFBVWLLJEARXPV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 3139   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM3139 (2-pyridinone deriv. 45 | 5-ethyl-3-{[(3-methoxypyr...) Show SMILES CCc1cc(NCc2ncccc2OC)c(=O)[nH]c1C Show InChI InChI=1S/C15H19N3O2/c1-4-11-8-12(15(19)18-10(11)2)17-9-13-14(20-3)6-5-7-16-13/h5-8,17H,4,9H2,1-3H3,(H,18,19)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	8.2	n/a
Merck Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 36: 249-55 (1993) Article DOI: 10.1021/jm00054a009 BindingDB Entry DOI: 10.7270/Q20863HM
					More data for this Ligand-Target Pair