BDBM31482 substituted biphenyl derivative, 36v

SMILES: CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccccc1

InChI Key: InChIKey=GVACGRWTTRFLEX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 31482   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor VII (Homo sapiens (Human))	BDBM31482 (substituted biphenyl derivative, 36v) Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C32H30N4O4/c1-19(2)18-35-30(37)23-11-15-26(28(17-23)32(39)40)25-14-10-22(20-6-4-3-5-7-20)16-27(25)31(38)36-24-12-8-21(9-13-24)29(33)34/h3-17,19H,18H2,1-2H3,(H3,33,34)(H,35,37)(H,36,38)(H,39,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	98	n/a	n/a	n/a	n/a	7.2	23
BioCryst Pharmaceuticals					Assay Description TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...				Bioorg Med Chem 17: 3934-58 (2009) Article DOI: 10.1016/j.bmc.2009.04.013 BindingDB Entry DOI: 10.7270/Q2SX6BJN
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM31482 (substituted biphenyl derivative, 36v) Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C32H30N4O4/c1-19(2)18-35-30(37)23-11-15-26(28(17-23)32(39)40)25-14-10-22(20-6-4-3-5-7-20)16-27(25)31(38)36-24-12-8-21(9-13-24)29(33)34/h3-17,19H,18H2,1-2H3,(H3,33,34)(H,35,37)(H,36,38)(H,39,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	25
BioCryst Pharmaceuticals					Assay Description FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...				Bioorg Med Chem 17: 3934-58 (2009) Article DOI: 10.1016/j.bmc.2009.04.013 BindingDB Entry DOI: 10.7270/Q2SX6BJN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM31482 (substituted biphenyl derivative, 36v) Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C32H30N4O4/c1-19(2)18-35-30(37)23-11-15-26(28(17-23)32(39)40)25-14-10-22(20-6-4-3-5-7-20)16-27(25)31(38)36-24-12-8-21(9-13-24)29(33)34/h3-17,19H,18H2,1-2H3,(H3,33,34)(H,35,37)(H,36,38)(H,39,40)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a	25
BioCryst Pharmaceuticals					Assay Description Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...				Bioorg Med Chem 17: 3934-58 (2009) Article DOI: 10.1016/j.bmc.2009.04.013 BindingDB Entry DOI: 10.7270/Q2SX6BJN
					More data for this Ligand-Target Pair
Trypsin (Bos taurus (bovine))	BDBM31482 (substituted biphenyl derivative, 36v) Show SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccccc1 Show InChI InChI=1S/C32H30N4O4/c1-19(2)18-35-30(37)23-11-15-26(28(17-23)32(39)40)25-14-10-22(20-6-4-3-5-7-20)16-27(25)31(38)36-24-12-8-21(9-13-24)29(33)34/h3-17,19H,18H2,1-2H3,(H3,33,34)(H,35,37)(H,36,38)(H,39,40)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	25
BioCryst Pharmaceuticals					Assay Description Trypsin assay reactions were performed in a mixture containing trypsin, and test compounds were added at varied concentrations. The reactions were in...				Bioorg Med Chem 17: 3934-58 (2009) Article DOI: 10.1016/j.bmc.2009.04.013 BindingDB Entry DOI: 10.7270/Q2SX6BJN
					More data for this Ligand-Target Pair