null

SMILES: Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1

InChI Key: InChIKey=JNRNJLLAPRHTBB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 314847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM314847 ((3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-...) Show SMILES Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9| Show InChI InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM314847 ((3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-...) Show SMILES Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9| Show InChI InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM314847 ((3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-...) Show SMILES Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9| Show InChI InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM314847 ((3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-...) Show SMILES Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9| Show InChI InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM314847 ((3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-...) Show SMILES Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9| Show InChI InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	143	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM314847 ((3-methyl-2-(oxazol-2-yl)phenyl)((1S,4R,6R)-6-((5-...) Show SMILES Cc1ccc(OC2CC3CC2N(C3)C(=O)c2cccc(C)c2-c2ncco2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9| Show InChI InChI=1S/C23H23N3O3/c1-14-6-7-20(25-12-14)29-19-11-16-10-18(19)26(13-16)23(27)17-5-3-4-15(2)21(17)22-24-8-9-28-22/h3-9,12,16,18-19H,10-11,13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	149	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair