null

SMILES: Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1

InChI Key: InChIKey=XQUHVGGAYSDNKI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 315088   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM315088 (((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicy...) Show SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12| Show InChI InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Rattus norvegicus (Rat))	BDBM315088 (((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicy...) Show SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12| Show InChI InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM315088 (((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicy...) Show SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12| Show InChI InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1×...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM315088 (((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicy...) Show SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12| Show InChI InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM315088 (((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicy...) Show SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12| Show InChI InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	363	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1× pen-strep...				US Patent US10183953 (2019) BindingDB Entry DOI: 10.7270/Q2Z60R5Q
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM315088 (((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicy...) Show SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1 |TLB:16:14:11.12:9.8,THB:6:8:14.15:11.12| Show InChI InChI=1S/C23H20BrFN4O2/c24-15-6-8-20(28-12-15)31-19-11-14-5-7-18(19)29(13-14)23(30)16-3-1-4-17(25)21(16)22-26-9-2-10-27-22/h1-4,6,8-10,12,14,18-19H,5,7,11,13H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	363	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...				US Patent US9611277 (2017) BindingDB Entry DOI: 10.7270/Q24B33D2
					More data for this Ligand-Target Pair