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BDBM3156 2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzene)amido]-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid::Balanol analog 22::Balanol analog 23

SMILES: CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1

InChI Key: InChIKey=DWBQHQGWEQXPKL-CCOUQBIQSA-N

Data: 18 IC50

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 3156   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 3.40E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 4.40E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.20E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 1.40E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.20E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 4.60E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 4.90E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA)


(Bos taurus (bovine))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1 |r,TLB:19:17:3.4:1,0:1:3.4:6.17.18,THB:7:6:3.4:1|
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 3.50E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair