BDBM318026 2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8-methyl-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-4-one::US9624218, Example 20::US9624218, Example 28

SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1

InChI Key: InChIKey=MXRLSJYSHPXDBN-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 318026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318026 (2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1 Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31.8	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318026 (2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1 Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318026 (2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1 Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318026 (2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1 Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.8	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318026 (2-[4-[(3-Fluoro-2-pyridyl)methyl]piperazin-1-yl]-8...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncccc2F)CC1 Show InChI InChI=1S/C18H23FN6O/c1-23-7-3-4-13-16(23)21-18(22-17(13)26)25-10-8-24(9-11-25)12-15-14(19)5-2-6-20-15/h2,5-6H,3-4,7-12H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29.5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair