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SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1

InChI Key: InChIKey=VLKQIEMXMFAOES-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 318034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318034 (8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318034 (8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.54	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318034 (8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.57E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318034 (8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.6	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318034 (8-Methyl-2-[4-[[3-trifluoromethyl)-2- pyridyl]meth...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ccccc2C(F)(F)F)CC1 Show InChI InChI=1S/C20H24F3N5O/c1-26-8-4-6-15-17(26)24-19(25-18(15)29)28-11-9-27(10-12-28)13-14-5-2-3-7-16(14)20(21,22)23/h2-3,5,7H,4,6,8-13H2,1H3,(H,24,25,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26.2	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair