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SMILES: CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1

InChI Key: InChIKey=WTVLTJMRTHFMJP-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318038   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM318038 (2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1 Show InChI InChI=1S/C17H22FN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM318038 (2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1 Show InChI InChI=1S/C17H22FN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM318038 (2-[4-[(5-Fluoropyrimidin-2-yl)methyl]piperazin-1-y...) Show SMILES CN1CCCc2c1nc([nH]c2=O)N1CCN(Cc2ncc(F)cn2)CC1 Show InChI InChI=1S/C17H22FN7O/c1-23-4-2-3-13-15(23)21-17(22-16(13)26)25-7-5-24(6-8-25)11-14-19-9-12(18)10-20-14/h9-10H,2-8,11H2,1H3,(H,21,22,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.9	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...				US Patent US9624218 (2017) BindingDB Entry DOI: 10.7270/Q26112CZ
					More data for this Ligand-Target Pair