null

SMILES: COc1ncc(cn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2ccccc2)C1

InChI Key: InChIKey=QPXVIPHIGFXHTC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 318406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318406 (US10301317, Example 364 | US9624228, Example 364) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2ccccc2)C1 Show InChI InChI=1S/C27H24N6O2/c1-35-27-28-13-20(14-29-27)25-22-11-19-10-21(26(34)30-23(19)12-24(22)31-32-25)18-8-5-9-33(16-18)15-17-6-3-2-4-7-17/h2-4,6-7,10-14,18H,5,8-9,15-16H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2GM89M0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM318406 (US10301317, Example 364 | US9624228, Example 364) Show SMILES COc1ncc(cn1)-c1n[nH]c2cc3[nH]c(=O)c(cc3cc12)C1CCCN(Cc2ccccc2)C1 Show InChI InChI=1S/C27H24N6O2/c1-35-27-28-13-20(14-29-27)25-22-11-19-10-21(26(34)30-23(19)12-24(22)31-32-25)18-8-5-9-33(16-18)15-17-6-3-2-4-7-17/h2-4,6-7,10-14,18H,5,8-9,15-16H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
Kura Oncology, Inc. US Patent					Assay Description The inhibition of ERK activity by the compounds disclosed herein was determined using the Z′-LYTE kinase assay kit (Life Technologies) with a S...				US Patent US9624228 (2017) BindingDB Entry DOI: 10.7270/Q22809PP
					More data for this Ligand-Target Pair