null

SMILES: COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(CF)n2c1

InChI Key: InChIKey=KKQGFFSHWVTNMA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318856   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM318856 (6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(fluoromethy...) Show SMILES COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(CF)n2c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-14-11-18(13-31-19(12-27)28-29-24(14)31)33-22(16-5-7-17(26)8-6-16)23-20(25(33)34)21(15-3-4-15)30-32(23)9-10-35-2/h5-8,11,13,15,22H,3-4,9-10,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM318856 (6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(fluoromethy...) Show SMILES COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(CF)n2c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-14-11-18(13-31-19(12-27)28-29-24(14)31)33-22(16-5-7-17(26)8-6-16)23-20(25(33)34)21(15-3-4-15)30-32(23)9-10-35-2/h5-8,11,13,15,22H,3-4,9-10,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...				US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02
					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 (Homo sapiens (Human))	BDBM318856 (6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(fluoromethy...) Show SMILES COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(CF)n2c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-14-11-18(13-31-19(12-27)28-29-24(14)31)33-22(16-5-7-17(26)8-6-16)23-20(25(33)34)21(15-3-4-15)30-32(23)9-10-35-2/h5-8,11,13,15,22H,3-4,9-10,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 (Homo sapiens (Human))	BDBM318856 (6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(fluoromethy...) Show SMILES COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(CF)n2c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-14-11-18(13-31-19(12-27)28-29-24(14)31)33-22(16-5-7-17(26)8-6-16)23-20(25(33)34)21(15-3-4-15)30-32(23)9-10-35-2/h5-8,11,13,15,22H,3-4,9-10,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02
					More data for this Ligand-Target Pair