BDBM318864 5-(8-amino-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-6-(4-chlorophenyl)-3-cyclopropyl-1-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(1H)-one::US9624247, Example 28
SMILES: Cc1nnc2c(N)cc(cn12)N1C(c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1
InChI Key: InChIKey=FRDVUWTYVBTBSE-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM318864![]() (5-(8-amino-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CREB-binding protein (Homo sapiens (Human)) | BDBM318864![]() (5-(8-amino-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ... | US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 3 (Homo sapiens (Human)) | BDBM318864![]() (5-(8-amino-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 2 (Homo sapiens (Human)) | BDBM318864![]() (5-(8-amino-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG US Patent | Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | US Patent US9624247 (2017) BindingDB Entry DOI: 10.7270/Q28S4S02 | |||||||||||
More data for this Ligand-Target Pair |