BDBM318882 N-(4-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide::US10172868, Compound C067::US10653701, Compound C067

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cc(NC(=O)C=C)ccc4F)c3n2)cc1

InChI Key: InChIKey=VVTRDVWQQQVVON-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 318882   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318882 (N-(4-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)pheny...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cc(NC(=O)C=C)ccc4F)c3n2)cc1 Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-9-12-25(29)24(17-21)23-6-4-5-19-18-30-28(33-27(19)23)32-20-7-10-22(11-8-20)35-15-13-34(2)14-16-35/h3-12,17-18H,1,13-16H2,2H3,(H,31,36)(H,30,32,33)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description (i) Peptide/Kinase Mixtures for measurement of EGFR (ErbB1):The 2×EGFR (ErbB1)/Tyr 04 mixture is prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM...				US Patent US10653701 (2020)
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human))	BDBM318882 (N-(4-fluoro-3-(2-((4-(4-methylpiperazin-1-yl)pheny...) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cc(NC(=O)C=C)ccc4F)c3n2)cc1 Show InChI InChI=1S/C28H27FN6O/c1-3-26(36)31-21-9-12-25(29)24(17-21)23-6-4-5-19-18-30-28(33-27(19)23)32-20-7-10-22(11-8-20)35-15-13-34(2)14-16-35/h3-12,17-18H,1,13-16H2,2H3,(H,31,36)(H,30,32,33)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
NEUPHARMA, INC. US Patent					Assay Description The compound of Formula I binds to a kinase selected from the group consisting of EGFR, EGFR L858R, EGFR T790M, EGFR del E746-A750, or EGFR L858R/T79...				US Patent US10172868 (2019) BindingDB Entry DOI: 10.7270/Q25141BX
					More data for this Ligand-Target Pair